Introduction
and History
Nuclear Magnetic
Resonance (NMR) spectroscopy is a technique that provides
high resolution information about the structure and dynamics
of molecules in solution at the atomic level. It used to
study a wide variety of molecules from small drug like molecules
to macromolecules such as proteins and nuceic acids.
The NMR Core
facilities provideaccess to state of the art instrumentation
to researchers at UCHSC and its affiliated institutions
for the study of the structure and function of biological
macromolecules. NMR core staff and faculty provide assistance
to other users through training or through the development
of collaborations.
The NMR core
was established in 1996 through a grant from the Howard
Hughes Medical Institue and the National Cancer Institute.
Ongoing support for the NMR facility is provided primarily
by the University of Colorado
Cancer Center and the School
of Medicine.
The NMR facility
is located in Room L18-1300 on the first floor of the RC-1
South Building on UCHSC campus at Fitzsimons.
The facility
has Varian
INOVA spectrometers operating at 500 MHz and 600 MHz, and
an 800 MHz NMR spectrometer, which is located at the UC
Boulder campus. Recently a
900 MHz spectrometer was installed in the facility as
part of the Rocky Mountain Regional NMR Resource. A variety
of probes are available that are suitable for the solution
NMR studies of biological macromolecules including proteins,
nucleic acids and carbohydrates. There is a small wet lab
that can be used for sample manipulations, and an office/computer
room for visitors while using the facility.
Information on
access to the core, user fees, documentation etc, can be
found through the links at the top of this page, or by contacting
one of the individuals below.
Contacts
David
Jones
Tel. (303) 724-3600
Fax (303) 724-3663
Department of Pharmacology
University of Colorado Health Sciences Center
P.O. Box 6508, Mail Stop 8303
Aurora, CO 80045
Brad
Bendiak
Tel. (303) 724-3453
Fax (303) 724-3420
Department of
Cellular and Structural Biology
University of Colorado Health Sciences Center
P.O. Box 6511, Mail Stop 8108
Aurora, CO 80045
Please send comments
regarding these pages to: David
Jones
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