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Research The primary
users of the X-ray core facility include Drs. Mair
Churchill (Pharmacology), Jeffrey
Kieft (Biochemistry and Molecular Genetics), David
Jones (Pharmacology), and Rui
Zhao (Biochemistry and Molecular Genetics). In addition, these primary
users collaborate with Drs. Bob Sclafani, Jessica Tyler, Charles McHenry (Biochemistry
and Molecular Genetics), Michael Holers (Immunology), Bob Garcia (Pediatrics),
Aleem Siddiqui (Microbiology), Dean Edwards (Pathology), and Heide Ford (Obstetrics
& Gynecology) in a variety of research areas. Some recent publications by
these users are listed below. W.T. Watson, T. D. Minogue, Dale L. Val, S.
Beck von Bodman, and M.E.A.
Churchill (2002). Structural Basis and Specificity
of Acyl-homoserine
lactone Signal Production in Bacterial Quorum Sensing.
Molecular Cell, in press.
W.T. Watson, F.V. Murphy IV, T.A.
Gould, P. Jambeck, D. L. Val, J. E.
Cronan,Jr., S. Beck von Bodman, and M.E.A.
Churchill (2001) Crystallization and Rhenium MAD Phasing of the Acyl-homoserinelactone
Synthase EsaI. Acta Crystallographica, D57, 1945-1949. Szakonyi,
G., J. Guthridge, D. Li, K. Young, M. Holers, and X. Chen (2001). Structure of
complement receptor type 2 in complex with its ligand c3d. Science 292,
1725-1728. Chen, X., G. Casini, S.C. Harrison, and R. Garcia (2001). Papillomavirus
capsid protein expression in Escherichia coli: purification and assembly of HPV11
and HPV16 L1. J. Mol. Biol. 307, 173-182. R.D. Scavetta, C.B. Thomas,
M.A. Walsh, S. Szegedi, A. Joachimiak, R.I.
Gumport, M.E.A. Churchill (2000).
Structure of RsrI methyltransferase, a member of the N6-Adenine b class of DNA
methyltransferases. Nucleic Acids Research, 28, 3950-3961.
L.K.
Dow, D.N.M. Jones, S.A. Wolfe, G.L. Verdine, and M.E.A. Churchill (2000). Structural
Studies of the High Mobility Group Globular Domain and Basic Tail of HMG-D Bound
to Disulfide Cross-linked DNA. Biochemistry 39, 9725-9736. F.V.
Murphy IV, R. M. Sweet, & M.E.A. Churchill (1999). The Structure of a Chromosomal
High-Mobility-Group Protein-DNA Complex Reveals Sequence-neutral Mechanisms Important
for Non-sequence-specific DNA Recognition. EMBO J. 18, 6610-6618. F.V.
Murphy IV, J. V. Sehy, Y.G. Gao, L.K. Dow & M.E.A. Churchill (1999). Co-crystallization
and Preliminary Crystallographic Analysis of the HMG
Domain of HMG-D Bound
to DNA. Acta Crystallographica D55, 1594-1597.
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