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Structural Models of Receptor Targets in the Low Homology
or New Fold Region - The first component of this will be the creation of structural
models of proteins whose sequence is known but no structures from experimental
techniques, e.g. X-ray crystallography, NMR or cryo-electronmicroscopy, are likely
to be available in the near future. Depending on the sequence similarity of the
unknown protein with proteins of known structure, either homology modeling methods
or fold recognition techniques will be used. For critical proteins which do not
appear to have any known structural homologues, new fold protein modeling techniques
will be used, although such structures will have a relatively low reliable resolution. |
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