Boris Tabakoff, Ph.D. Professor
and Chairman of Pharmacology
Faculty Fellow, Institute for Behaviorial Genetics
at
Boulder, Colorado Department of
Pharmacology
School of Medicine
University of Colorado Health Sciences
Center
P.O. Box 6511, Mail Stop 8303
Aurora, CO 80045 Phone:
(303) 724-3668
Fax: (303) 724-3664
Boris.Tabakoff@uchsc.edu EDUCATION/EXPERIENCE
HONORS, AWARDS & PATENTS PROFESSIONAL
ACTIVITIES LAB PERSONNEL Research
Interests The research in
my laboratory focuses on the process of neural adaptation in response to ingestion
of addictive substances, and, in particular, alcohol. The techniques of molecular
pharmacology are used to examine neuronal signal transduction mechanisms and second
messenger systems, as well as to study excitatory amino acid receptors that are
coupled to ion channels. In particular, studies focus on the NMDA subtype of glutamate
receptor which we have shown to be intimately involved in physical dependence
on alcohol and on adenylyl cyclase systems which are postulated to predispose
individuals to development of alcoholism. Research is performed using cells in
culture, animal models including null-mutant and transgenic mice and human subjects.
Selected Publications -
Snell LD, Bhave SV,
Tabakoff B, Hoffman PL. Chronic ethanol exposure delays the 'developmental
switch' of the NMDA receptor 2A and 2B subunits in cultured cerebellar granule
neurons. J Neurochem. 2001 Jul;78(2):396-405. [Abstract] -
Wu PH, Tabakoff B, Szabo G, Hoffman PL. Chronic ethanol exposure results
in increased acute functional tolerance in selected lines of HAFT and LAFT mice.
Psychopharmacology (Berl). 2001 Jun;155(4):405-12. [Abstract] -
Kirstein SL, Tabakoff B. Genetic correlations between initial sensitivity
to Ethanol and brain cAMP signaling in inbred and selectively bred mice.
Alcohol
Clin Exp Res. 2001 Jun;25(6):791-9. [Abstract] -
Tabakoff B, Helander A, Conigrave KM, Martinez L, Hoffman PL, Whitfield
J, Degenhardt L, Saunders J, Baron A, Glanz J. WHP/ISBRA study on state and trait
markers in alcoholism. Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):99S-103S.
[Abstract] -
Hoffman PL, Yagi T, Tabakoff B, Phillips TJ, Kono H, Messing RO, Choi
DS. Transgenic and gene "knockout" models in alcohol research. Alcohol
Clin Exp Res. 2001 May;25(5 Suppl ISBRA):60S-66S. Review. [Abstract] -
Tabakoff B, Hoffman PL. Animal models in alcohol research. Alcohol Res
Health. 2000;24(2):77-84. Review. [Abstract] -
Tabakoff B, Nelson E, Yoshimura M, Hellevuo K, Hoffman PL. Phosphorylation
cascades control the actions of ethanol on cell cAMP signalling. J Biomed Sci.
2001 Jan-Feb;8(1):44-51. Review. [Abstract] -
Yoshimura M, Wu PH, Hoffman PL, Tabakoff B. Overexpression of type
7 adenylyl cyclase in the mouse brain enhances acute and chronic actions of morphine.
Mol Pharmacol. 2000 Nov;58(5):1011-6. [Abstract] -
Bhave SV, Snell LD, Tabakoff B, Hoffman PL. Chronic ethanol exposure
attenuates the anti-apoptotic effect of NMDA in cerebellar granule neurons. J
Neurochem. 2000 Sep;75(3):1035-44. [Abstract] -
Menninger JA, Baron AE, Conigrave KM, Whitfield JB, Saunders JB, Helander A, Eriksson
CJ, Grant B, Hoffman PL, Tabakoff B. Platelet adenylyl cyclase activity
as a trait marker of alcohol dependence. WHO/ISBRA Collaborative Study Investigators.
International Society for Biomedical Research on Alcoholism. Alcohol Clin Exp
Res. 2000 Jun;24(6):810-21. [Abstract]
 Bibliography
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