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 Lawrence
Hunter, Ph.D.
Associate Professor of Pharmacology
Department of Pharmacology
University of Colorado at Denver
and Health Sciences Center
RC1 South Tower, Room 6101
P.O. Box 6508 MS 8303
Aurora, Colorado 80045
Phone: 303.724-3574
Fax: 303.724-3663
Larry.Hunter@uchsc.edu
EDUCATION/EXPERIENCE
HONORS & AWARDS
Research Interests:
My research interests involve
the development and application of advanced computational techniques to biomedicine,
particularly the application of machine learning and statistical inference techniques
to high-throughput molecular assays. I am also interested in automated processing
of biomedical texts, anatomically realistic models of neural computation, and
neurobiologically and evolutionarily informed computational models of cognition.
As one of the founders of the field of bioinformatics, I have explored applications
of computational techniques to a wide variety of biological problems, including
protein structure, macromolecular sequence analysis, combinatorial chemistry and
managing the enormous biomedical literature. The current focus of my laboratory
is on developing novel techniques for the analysis of gene expression array data
for the inference of metabolic and signaling pathways from genetic, proteomic
and transcriptional data, and for the management of large collections of biomedical
documents. Our primary computational tools are the algorithms of machine learning
and natural language processing.
Selected Publications
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GEST: A Gene Expression Search Tool Based on a Novel
Bayesian Similarity Metric, with Ronald C. Taylor, Sonia M. Leach and Richard
Simon. Bioinformatics, (in press)
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Visual Management of Large Scale Data Mining Projects, with Imran Shah. Pacific
Symposium on Biocomputing, 5:275-287, 2000.
[Abstract]
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Edgar: Extraction of Drugs, Genes and Relations from the Biomedical Literature,
with Thomas C. Rindflesch, Lorraine Tanabe,and John N. Weinstein, Pacific Symposium
on Biocomputing, 5:514-525, 2000.
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MedMiner: An Internet Tool for Filtering and Organizing Biomedical Information,
with Lorraine Tanabe and John N. Weinstein . Biotechniques, 27(6):1210-7, Dec
1999. [Abstract]
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Mining Molecular Binding Terminology from Biomedical Text, with Thomas C.
Rindflesch and Alan R. Aronson. Proceedings of American Medical Informatics Association
Symposium, (1-2):127-31, 1999.
[Abstract]
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Identification of divergent functions in homologous proteins by induction
over conserved modules, with Imran Shah. Intelligent Systems for Molecular Biology
6:157-64 (1998). [Astract]
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Visualization Based on the Enzyme Commission Nomenclature, with I. Shah. Pacific
Symposium on Biocomputing 3:142-152 (1998).[Abstract]
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Characterization of a Family of Chimeric Proteins, the Amino
Acyl tRNA Synthetases, by Determining Differential Codon Usage
using One and Two State HMMs, with Barry R. Zeeberg, Mathematical
Modeling and Scientific Computation, 9(1):58-67, 1998.
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A Hidden Markov Model Whose Alphabet Is Nucleic Acid Triplet Codons and its
Use to Discover Chimerism in Protein Families, with Barry R. Zeeberg, Intelligent
Systems for Molecular Biology 5:153-156 , Menlo Park, CA: AAAI Press, 1997.[Abstract]
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Functional Classification of Enzymes by Sequence Alignment, with Imran Shah,
Intelligent Systems for Molecular Biology, 5:276-83 , Menlo Park, CA: AAAI Press
1997.[Abstract]
Bibliography
Dr. Hunter's Departmental
Website
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