Uwe Christians, M.D., Ph.D.

Associate Professor of Anesthesiology

Department of Anesthesiology
University of Colorado at Denver and Health Sciences Center
4200 E. Ninth Avenue, Box B113
Denver, CO 80262
Office: AOB Rm 156

Phone: 303.315-1845

Uwe.christians@uchsc.edu

EDUCATION/EXPERIENCE

AWARDS, MEMBERSHIPS & FELLOWSHIPS

PROFESSIONAL ACTIVITIES

Research Interests:

Pharmacology - effects of immunosuppressants on cell metabolism, drug metabolism and drug transport, clinical pharmacokinetics
Toxicology - active transport of anesthetics across lung endothelium cells and the blood brain barrier in cell cultures, perfused organs and animal models
Mass Spectrometry and Proteomics - evaluate the role of statin lactones in pharmacokinetic interactions and muscle toxicity using biochemical profiling and proteomics
Computational Biology - metabolomics technology development

Selected Publications

Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Br J Pharmacol 2004; 143: 388-396.

Jacobsen W, Unger M, Niemann C, Baloum M, Hirai S, Benet LZ, Christians U. Automated, fast and sensitive quantification of drugs in human plasma by LC/LC-MS: Simultaneous quantification of six protease inhibitors and three non-nucleoside transcriptase inhibitors. Ther Drug Monit 2004; 26: 546-562.

Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U. Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-Coa reductase inhibitor atorvastatin. Drug Metab Dispos 28 (2000) 1369-1378.

Bibliography