David L. Bain, Ph.D.
Assistant Professor of Molecular Biophysics
School of Pharmacy
Department of Pharmaceutical Sciences
University of Colorado at Denver and Health Sciences Center
Campus Box C238
4200 East Ninth Avenue
Denver, Colorado 80262
Office Phone: 303.315.1416
Lab Phone: 303.315.1226
David.Bain@uchsc.edu
EDUCATION
PROFESSIONAL
ACTIVITIES
Research Interests
Physical chemistry of protein-protein
and protein-DNA interactions; thermodynamic, structural, and molecular
biological studies of progesterone receptors and transcriptional
coregulators.
Selected Publications
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McManaman JL and Bain DL. "Structural and conformational
analysis of the oxidase to dehydrogenase conversion of xanthine
oxidoreductase." J Biol Chem. 2002 277(24):21261-8.
[Abstract]
-
Graham JD, Bain DL, Richer
JK, Jackson TA, Tung L, Horwitz KB. Nuclear receptor conformation,
coregulators, and tamoxifen-resistant breast cancer. Steroids.
2000 Oct-Nov;65(10-11):579-84.
[Abstract]
-
Bain DL, Franden MA, McManaman JL, Takimoto GS, Horwitz KB.
The N-terminal region of the human progesterone A-receptor.
Structural analysis and the influence of the DNA binding domain.
J Biol Chem. 2000 Mar 10;275(10):7313-20.
[Abstract]
-
Bain DL, Ackers GK. A quantitative cryogenic gel-shift technique
for analysis of protein-DNA binding. Anal Biochem. 1998 May
1;258(2):240-5.
[Abstract]
-
Jackson TA, Richer JK, Bain DL,
Takimoto GS, Tung L, Horwitz KB. The partial agonist activity
of antagonist-occupied steroid receptors is controlled by a
novel hinge domain-binding coactivator L7/SPA and the corepressors
N-CoR or SMRT. Mol Endocrinol. 1997 Jun;11(6):693-705.
[Abstract]
-
Horwitz KB, Jackson TA, Bain DL,
Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators
and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. Review.
[Abstract]
-
Bain DL, Ackers GK. Self-association
and DNA binding of lambda cI repressor N-terminal domains reveal
linkage between sequence-specific binding and the C-terminal
cooperativity domain. Biochemistry. 1994 Dec 13;33(49):14679-89.
[Abstract]
-
Lane P, Vichi P, Bain DL,
Tritton TR. Temperature dependence studies of adriamycin uptake
and cytotoxicity. Cancer Res. 1987 Aug 1;47(15):4038-42.
[Abstract]
-
Ostrowski LE, Ahsan A, Suthar BP, Pagast P,
Bain DL, Wong C, Patel A, Schultz RM. Selective inhibition
of proteolytic enzymes in an in vivo mouse model for experimental
metastasis. Cancer Res. 1986 Aug;46(8):4121-8.
[Abstract]
Bibliography
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