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Christine C. Wu, Ph.D.
Assistant Professor of Pharmacology
School of Medicine
Department of Pharmacology
University of Colorado at Denver and Health Sciences Center
Campus Box MS8303
PO Box 6508
Aurora, CO 80045
Office Phone: 303.724-3351
Fax: 303 724-3663
email: Christine.Wu@uchsc.edu
EDUCATION
PROFESSIONAL
ACTIVITIES
Research Interests
Mass Spectroscopy/Proteomics
1) method development for the analysis of integral membrane proteins
within complex biological samples
2) identification of lipid embedded amino acid residues of membrane
proteins using mass spectrometry
3) biomarker profiling for fatty liver disease, heart failure,
and alcoholism
Macromolecule structure
1) high-throughput characterization of membrane protein topology
using mass spectrometry
2) identification of protein modifications
Selected Publications
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Klammer, AA, Wu, CC, MacCoss, MJ, Noble, WS. (2005). Peptide
charge state determination for low-resolution tandem mass spectra.
Proc IEEE Comput Syst Bioinform Conf. 2005:175-85.
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Miranda, M, Wu, CC, Korstjens, DR, Sorkina, T, Sorkin A. (2005).
Enhanced ubiquitylation and accelerated degradation of the dopamine
transporter mediated by protein kinase C. J. Biol. Chem. 280(42),
35617-35624.
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Wilson, AC, Wu, CC, Yates III, JR, Tan, M. (2005). Chlamydial
GroEL auto-regulates its own expression through direct interactions
with the HrcA repressor protein. J. Bacteriol. 187, 7535-7542.
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MacCoss, MJ, Wu, CC, Matthews, DE, Yates III, JR. (2005). Measurement
of the atomic enrichment of stable isotope labeled proteins
using high resolution mass spectra of peptides. Anal. Chem.
77, 7646-7653.
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Blackler, AR, Klammer, AA, MacCoss MJ, Wu, CC. (2006). Quantitative
comparison of proteomic data quality between a 2D and 3D quadrupole
ion trap. Anal. Chem. 78(4), 1337-1344.
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Miles, MF, MacLaren, EJ, Karimpour-Fard, A, Cai, W, Pollack,
J, Hitzemann, R, Belknap, J, McWeeney, S, Kerns, RT, Downing,
C, Johnson, TE, Grant, KJ, Tabakoff, B, Hoffman, P, Wu, CC,
and Sikela, JM. (2006). DNA microarray and proteomic strategies
for understanding alcohol action. Alcohol Clin Exp Res. 30(4),
700-708.
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Frewen, BE, Merrihew, GE, Wu, CC, Noble, WS, MacCoss, MJ. (2006).
Library searching for identifying peptide MS/MS spectra. Anal.
Chem. 78(16):5678-5684.
Bibliography
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