Gongyi Zhang, Ph.D.

Educational Background

• June 1988: Bachelor of Engineering; Dalian Maritime University, Dalian, P. R. China

• June 1990: M.S. (equivalent) in Protein Crystallography; University of Science and Technology of China (USTC), Hefei, P. R. of China

• Sept. 1993: Ph.D. in Protein Crystallography; Institute of Biophysics, Academic Sinica, Beijing, P. R. of China

Professional Experience

• 1999-present: Assistant Professor, Departments of Immunology and Pharmacology, National Jewish Medical and Research Center and School of Medicine, University of Colorado Health Science Center (UCHSC)

• Structural and functional studies of SarA, SarR, SarS, Rat and their complexes with DNAs.
  

• Structure and function studies of RNA polymerase holoenzyme with its regulator proteins from thermus aquaticu.
  

• Structural and functional studies of membrane proteins (e.g. pIV, GABA receptors, Ca2+ channels, Na+/K+ channels, and adenylyl Cyclase).
  

• Structural and functional studies of signal transduction proteins, apoptotic proteins, and T-cell related proteins.
  

• Structural and functional studies of TALL-1 (TNF family member) and its receptors and their signal transduction mechanism.

• 1997-1999: Postdoctoral Fellow, Lab of Dr. Seth A. Darst, The Rockefeller University

  • Structure determination of the N-terminal domain of alpha subunit of RNA polymerase from E.coli at
    2.5 A°
    

  • Preliminary X-ray analysis of C-terminal domain of alpha subunit and whole length alpha subunit of RNA polymerase from E.coli
    

  • Structure determination of core RNA polymerase from Thermus aquaticus at 3.3 A° resolution

• 1993-1996: Visiting Fellow, Lab of Dr. James H. Hurley, NIDDK, NIH

  • Structure determination of protein Kinase C Zinc finger domain complexed with phorbol-13-acetate at 1.9 A°.
    

  • Structure determination of catalytic core of Adenylyl Cyclase with Forskolin at 2.2 A°.

• 1990-1993: Graduate Fellow, Lab of Professor Dong-Cai Liang,
  Institute of Biophysics, Academic Sinica, P. R. of China
  

  • High resolution structure determination of mutated procine insulins.
    

  • Purification and crystallization of F1-ATPase from porcine heart mitochondria.

• 1988-1990: Graduate Fellow, Lab of Professors Li-Wen Niu and Dong-Cai Liang, University of Science and Technology of China, P. R. of China
  

  • Structural studies of glucose isomerase from E. coli.
    

  • Purification and characterization of anti-coagulation and anti-hypertension factors from five-pace snake venom.