Robert C. Murphy, Ph.D.

Publications, 2001

1. Hevko J, Bowers RC, Murphy RC. Synthesis of 5-oxo-6,8,11,14-tetraenoic acid and identification of novel omega oxidized metabolites in the mouse macrophage. J Pharmacol Exp Ther 296:293-305 (2001).

2. Marathe GK, Harrison KA, Roberts L J 2nd, Morrow JD, Murphy RC, Tjoelker LW, Prescott SM, Zimmerman GA, McIntyre TM. Identification of platelet-activating factor as the inflammatory lipid mediator in CC14-metabolizing rat liver. J Lipid Res 42:587-596 (2001).

3. Murphy RC, Fiedler J, Hevko J. Analysis of nonvolatile lipids by mass spectrometry. Chemical Reviews 101: 479-526 (2001).

4. Hevko J, Murphy RC. Electrospray ionization and tandem mass spectrometry of cysteinyl eicosanoids: Leukotriene C4 and FOG7. J Am Soc Mass Spectrom 12:763-771 (2001).

5. Murphy RC. Free radical induced oxidation of arachidonoyl plasmalogen phospholipids: Antioxidant mechanism and precursor pathway for bioactive eicosanoids. Chem Res Toxicol 14:463-472 (2001).

6. Davies SS, Pontsler AV, Marathe GK, Harrison KA, Murphy RC, Hinshaw JC, Prestwich GD, St. Hilaire A, Prescott SM, Zimmerman GA, McIntyre TM. Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor ? ligands and agonists. J Biol Chem 276:16015-16023 (2001).

7. Fiedler J, Simon FR, Iwahashi M, Murphy RC. Effect of PPARa activation on leukotriene B4 metabolism in the isolated rat hepatocyte. J Pharmacol Exp Therap 299:691-697 (2001).

8. Mohapatra S, Capdevila JH, Murphy RC, Hevko JM, Falck JR. Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid. Tetrahedron Lett 42:4109-4110 (2001).

9. Liu Y, Manna A, Li R, Martin WE, Murphy RC, Cheung AL, Zhang G. Crystal structure of the SarR protein from Staphylococcus aureus. Proc Natl Acad Sci USA 98:6877-6882 (2001).

10. Storey MK, Clay KL, Kutateladze T, Murphy RC, Overduin M, Voelker DR. Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures. J Biol Chem 276:48539-48548 (2001).

11. Bauer AK, Dwyer-Nield LD, Hankin JA, Murphy RC, Malkinson AM. The lung tumor promoter, butylated hydroxytoluene (BHT), causes chronic inflammation in promotion-sensitive BALB/cByJ mice but not in promotion-resistant CXB4 mice. Toxicology 169:1-15 (2001).