Thomas A. Langan, Ph.D.
Langan, T.A., Durrum, E.L. and Jencks,
W.P.: Paper electrophoresis as a quantitative method: Measurement of
a- and b-lipoprotein cholesterol. J. Clin. Invest. 34, 1427-1436 (1955).
Shuster, L., Langan, T.A., Kaplan,
N.O. and Goldin, A.: Significance of induced in vivo synthesis of diphosphopyridine
nucleotide. Nature 182, 512-515 (1958).
Langan, T.A., Kaplan, N.O. and Shuster,
L.: Formation of the nicotinic acid analogue of diphosphopyridine nucleotide
after nicotinamide administration. J. Biol. Chem. 234, 2161-2168 (1959).
Narrod, S.A., Langan, T.A., Kaplan,
N.O. and Goldin, A.: Effect of azaserine on the pyridine nucleotide
levels of mouse liver. Nature 183, 1674-1675 (1959).
Theorell, H. and Langan, T.A.: Fluorometric
observations of binary and ternary complexes formed with malic dehydrogenase,
coenzyme and d-malic acid. Acta. Chem. Scand. 14, 933-935 (1960).
Langan, T.A.: Changes in the fluorescence
spectrum of reduced triphosphopyridine nucleotide on binding to isocitric
dehydrogenase. Acta. Chem. Scand. 14, 936-938 (1960).
Langan, T.A.: A phosphoprotein preparation
from liver nuclei and its effect on the inhibition of RNA synthesis
by histones. In Koningsberger, V.V. and Bosch, L. (eds.), Regulation
of Nucleic Acid and Protein Biosynthesis, B.B.A. Library, Vol. 10, p.
233-242, Elsevier, Amsterdam (1967).
Langan, T.A.: Histone phosphorylation:
Stimulation by adenosine 3':5'-monophosphate. Science 162, 579-580 (1968).
Langan, T.A.: Phosphorylation of
proteins of the cell nucleus. In San Pietro, A., Lamborg, M. and Kenney,
F. (eds), Regulatory Mechanisms for Protein Synthesis in Mammalian Cells,
Academic Press, N.Y. p. 101-118 (1968).
Meisler, M.H. and Langan, T.A.: Characterization
of a phosphatase specific for phosphorylated histones and protamine.
J. Biol. Chem. 244, 4961-4968 (1969).
Langan, T.A.: Action of adenosine
3':5'-monophosphate-dependent histone kinase in vivo. J. Biol. Chem.
244, 5763-5765 (1969).
Langan, T.A. Phosphorylation of liver
histone following the administration of glucagon and insulin. Proc.
Nat. Acad. Sci. 64, 1276-1283 (1969).
Langan, T.A.: Phosphorylation of
histones in vivo under the control of cyclic AMP and hormones. In E.
Costa and P. Greengard (eds.), Role of Cyclic AMP in Cell Function.
Advances in Biochemical Pharmacology, Vol. 3, p. 307-323, Raven Press,
New York (1970).
Langan, T.A.: Histone phosphorylation
and hormonal regulation of nuclear function. In E. Mihich (ed.), Drugs
and Cell Regulation, p. 63-78, Academic Press, N.Y. (1971).
Adler, A.J., Schaffhausen, B., Langan, T.A.
and Fasman, G.C.: Altered conformational effects of phosphorylated lysine-rich
histone (f1) in f1: DNA complexes: Circular dichroism and immunological
studies. Biochemistry 10, 909-913 (1971).
Langan, T.A., Rall, S.C. and Cole,
R.D.: Variation in primary structure at a phosphorylation site in lysine-rich
histone. J. Biol. Chem. 246, 1942-1944 (1971).
Langan, T.A.: Cyclic AMP and histone
phosphorylation. Ann. N.Y. Acad. Sci. 185, 166-180 (1971).
Adler, A.J., Langan, T.A. and Fasman,
G.D.: Complexes of deoxyribonucleic acid with lysine-rich f1 histone
phosphorylated at two separate sites: Circular dichroism studies. Arch.
Biochem. Biophys. 153, 769-777 (1972).
Mallette, L.E., Neblett, M., Exton, J.H. and Langan,
T.A.: Phosphorylation of lysine-rich histone in the isolated
perfused rat liver: Effects of glucagon, cyclic AMP and insulin. J.
Biol. Chem. 248, 6289-6291 (1973).
Langan, T.A. Protein kinases and
protein kinase substrates. In P. Greengard and G.A. Robinson (eds),
Advances in Cyclic Nucleotide Research, Vol. 3, p. 99-153, Raven Press,
New York (1973).
Bradbury E.M., Inglis, R.J., Matthews, H.R. and Langan,
T.A.: Molecular basis of control of mitotic cell division in
eukaryotes. Nature 249, 553-556 (1974).
Langan, T.A. and Hohmann, P.: Analysis
of specific phosphorylation sites in lysine-rich (H1) histone: An approach
to the determination of structural chromosomal protein functions. In
G.S. Stein and L. Kleinsmith (eds.), Chromosomal Proteins and Their
Role in the Regulation of Gene Expression, p. 113-125, Academic Press
(1975).
Inglis, R.J., Langan, T.A., Matthews,
H.R., Hardie, D.G. and Bradbury, E.M.: Advance of mitosis by histone
phosphokinase. Exper. Cell Res. 97, 418-425 (1976).
Rattle, H.W.E., Langan, T.A., Danby,
S.E. and Bradbury, E.M.: Studies on the role and mode of operation of
the very-lysine-rich histones in eukaryote chromatin. Effect of A and
B site phosphorylation on the conformation and interaction of histone
H1. Eur. J. Biochem. 81, 499-505 (1977).
Langan, T.A.: Methods for the assessment
of site-specific histone phosphorylation. In G.S. Stein and J. Stein
(eds.), Methods in Cell Biology, Vol. 19, p. 127-142, Academic Press,
New York (1978).
Langan, T.A.: Isolation of histone
kinases. In G.S. Stein and J. Stein (eds.), Methods in Cell Biology,
Vol. 19, p. 143-152, Academic Press, New York (1978).
Langan, T.A., Zeilig, C.E. and Leichtling,
B.: Analysis of multiple site phosphorylation of H1 histone. In G. Thomas,
E.J. Podesta and J. Gordon (eds), Protein Phosphorylation and Bio-Regulation,
pp. 70-82, S. Karger, Basel (1980).
Vulliet, P.R., Langan, T.A. and Weiner,
N. Tyrosine hydroxylase: A substrate of cyclic AMP-dependent protein
kinase. Proc. Natl. Acad. Sci. 77, 92-96 (1980).
Zeilig, C.E. and Langan, T.A.: Studies
on the mechanism of activation of mitotic histone H1 kinase. Biochem.
Biophys. Res. Comm. 95, 1372-1379 (1980).
Langan, T.A.: Malignant transformation
and protein phosphorylation. Nature 286, 329-330 (1980).
Wimalasena, J., Leichtling, B.H., Lewis, E.J., Langan,
T.A. and Wicks, W.D.: Coordinate regulation of adenylate cyclase,
protein kinase, and specific enzyme synthesis by cholera toxin in hormonally
unresponsive hepatoma cells. Arch. Biochem. Biophys. 205, 595-605 (1980).
Zeilig, C.E., Langan, T.A. and Glass,
D.B.: Sites in histone H1 selectively phosphorylated by guanosine 3':5'
- Monophosphate dependent protein kinase. J. Biol. Chem. 256, 994-1001
(1981).
Langan, T.A., Zeilig, C.E. and Leichtling,
B. Characterization of multiple-site phosphorylation of H1 histone in
proliferating cells. 8th Cold Spring Harbor Conference on Cell Proliferation:
Protein Phosphorylation (O.M. Rosen and E.G. Krebs, eds.), pp. 1039-1052
(1981).
Langan, T.A.: Characterization of
highly phosphorylated subcomponents of rat thymus H1 histone. J. Biol.
Chem. 257, 14835-14846 (1982).
Chambers, T.C., Langan, T.A., Matthews,
H.R. and Bradbury, M.E.: H1 histone kinases from nuclei of Physarum
polycephalum. Biochemistry 22, 30-37 (1983).
Andrews, D., Langan, T.A., and Weiner,
N.: Evidence for the involvement of cyclic AMP-independent protein kinase
in the activation of soluble tyrosine hydroxylase from rat striatum.
Proc. Natl. Acad. Sci. 80, 2097-2101 (1983).
Weiner, N., Yanagihara, N., Tank, A.W., Baizer, L. and Langan,
T.A.: Studies on the mechanism of activation of tyrosine hydroxylase
in situ in PC12 cells. In E. Usdin, A. Carlsson, A. Dahlstrom and J.
Engle (eds), Catecholamines, Basic and Peripheral Mechanisms, pp. 173-181,
Alan R. Liss, Inc., New York (1984).
Kaplan, L.J., Bauer, R., Morrison, E., Langan,
T.A. and Fasan, G.D.: The structure of chromatin reconstituted
with phosphorylated H1 histone. Circular dichroism and thermal denaturation
studies. J. Biol. Chem. 259, 8777-8785 (1984).
Weiner, N., Yanagihara, N., Tank, A.W. and Langan,
T.A.: Activation of tyrosine hydroxylase during K+-evoked depolarization
of PC12 cells: Involvement of protein phosphorylation. In W. Fleming,
K.H. Graetz, S.Z. Langer and N. Weiner (eds.), Neuronal and Extraneuronal
Events in Autonomic Pharmacology, pp. 1-11, Raven Press, New York (1984).
Yanagihara, N., Tank, A.W., Langan, T.A.
and Weiner, N.: Enhanced phosphorylation of tyrosine hydroxylase at
more than one site is induced by 56mM K+ in rat pheochromocytoma PC12
cells in culture. J. Neurochem. 46, 562-568 (1986).
Langan, T.A. and Chambers, T.C.:
Histone phosphorylation, cell cycle progression and chromatin structure.
In G.H. Sato, M.C. Cabot and W.L. McKeehan (eds.), Mechanisms of Signal
Transduction by Hormones and Growth Factors. Alan R. Liss, Inc., pp.
215-223 (1987).
Langan, T.A., Gautier, J., Lohka,
M., Hollingsworth, R., Moreno, S., Nurse, P., Maller, J., and Sclafani,
R.A.: Mammalian growth-associated H1 histone kinase: A homolog of cdc2+/CDC28
protein kinases controlling mitotic entry in yeast and frog cells. Mol.
Cell Biol. 9, 3860-3868 (1989).
Maller, J.L., Gautier, J., Langan, T.A.,
Shenoy, S., Shalloway, D. and Nurse, P.: Maturation-promoting factor
and the regulation of the cell cycle. J. Cell Sci. Suppl. 12, 53-63
(1989).
Chambers, T.C. and Langan, T.A.:
Purification and characterization of growth-associated H1 histone kinase
from Novikoff hepatoma cells. J. Biol. Chem. 265, 16940-16947 (1990).
Reeves, R., Langan, T.A. and Nissen,
M.S.: Phosphorylation of the DNA-binding domain of nonhistone high-mobility
group I protein by cdc2 kinase: Reduction of binding affinity. Proc.
Natl. Acad. Sci., 88, 1671-1675 (1991).
Chambers, T.C. and Langan, T.A.:
Purification and properties of growth-associated H1 histone kinase.
Methods in Enzymology, Vol. 200, 325-331, Academic Press, New York (1991).
Nissan, M.S., Langan, T.A. and Reeves,
R.: Phosphorylation by cdc2 kinase modulates DNA binding activity of
high mobility group I nonhistone chromatin protein. J. Biol. Chem. 266,
19945-19952 (1991).
Sola, M.M., Langan, T.A. and Cohen,
P.: p34cdc2 phosphorylation sites in histone H1 are dephosphorylated
by protein phosphatase 2A1. Biochim. Biophys. Acta 1094, 211-216 (1991).
Ferrigno, P., Langan, T.A. and Cohen,
P.: Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts
that dephosphorylates several physiological substrates for cyclin-dependent
protein kinases. Mol. Biol. Cell 4, 669-677 (1993).
Schauer, I., Siriwardana, S., Langan, T.A.
and Sclafani, R.A.: Cyclin D1 overexpression vs. Rb inactivation: implications
for growth control evasion in non-small cell and small cell lung cancer.
Proc. Nat. Acad. Sci. 91, 7827-7831 (1994).
Groshung, S.D., Owen, G.I., Grimison, B., Schauer, I.E., Todd, M.C.,
Langan, T.A., Sclafani, R.A., Lange,
C.A. and Horwitz, K.B.: Biphasic regulation of breast cancer cell growth
by progesterone: Role of cyclin-dependent kinase inhibitors, p21 and
p27Kip1. Mol. Endocrinol., 11, 1593-1607 (1997)
Sclafani, R.A., Schauer, I. and Langan,
T.A.: Alterations in cell cycle control in lung cancer, in "Biology
of Lung Cancer" Marcel Dekker, Inc. New York (1998).
Shellman, Y.G., Svee, E., Sclafani, R.A. and Langan,
T.A.: Identification and characterization of individual cyclin-dependent
kinase complexes from S. cerevisae. Yeast 15, 295-309 (1999).
Todd, M.C., Sclafani, R.A. and Langan, T.A.:
Ovarian cancer cells that coexpress endogenous Rb and p16 are insenstitive
to overexpression of functional p16 protein. Oncogene 19, 258-264 (2000).
Grimison, B., Langan, T.A. and Sclafani,
R.A.: p16Ink4a tumor suppressor function in lung cancer cells involves
cyclin-dependent kinase 2 inhibition by Cip/Kip protein redistribution.
Cell Growth Differentiation, 11, 507-515 (2000).
Todd, M.C., Sclafani, R.A., Franklin, W. and Langan,
T.A.: Resistance to overexpression of ectopic functional p16
protein in breast cancer cell lines expressing both Rb and p16. (in
preparation).
