Robert S. Hodges, Ph.D., F.R.S.C.

Publications, 1996

1. Monera, O.D., N.E. Zhou, P. Lavigne, C.M. Kay and R.S. Hodges. Formation of parallel and antiparallel coiled-coils controlled by the relative positions of alanine residues in the hydrophobic core. J. Biol. Chem. 271: 3995-4001 (1996).

2. Yu, Y., O.D. Monera, R.S. Hodges and P.L. Privalov. Ion-pairs significantly stabilize coiled-coils in the absence of electrolyte. J. Mol. Biol. 255: 367-372 (1996).

3. Lavigne, P., F.D. Sonnichsen, C.M. Kay and R.S. Hodges. Interhelical salt-bridges, coiled-coil stability and specificity of dimerization. Science 271: 1136-1138 (1996).

4. Mant, C.T. and R.S. Hodges. Analysis of peptides by HPLC. In "High Resolution Separation of Biological Macromolecules Part B Applications" (B.L. Karger and W.S. Hancock, Eds.), a volume of Methods of Enzymology, Academic Press, San Diego, CA, 271: 3-50 (1996).

5. Semchuk, P.D., O.D. Monera, L.H. Kondejewski, C. Gannon, L. Daniels, I. Wilson and R.S. Hodges. Preferential disulfide-bridge formation for hetero-dimers by derivatization with 2,2'-dithiodipyridine. In: Peptides: Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 73-74 (1996).

6. Kondejewski, L.H., D.S. Wishart, B.D. Sykes, C.M. Kay and R.S. Hodges. Design, synthesis and characterization of a peptide b-sheet model. In: Peptides: Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 68-70 (1996).

7. Houston, Jr., M.E., C.M. Kay and R.S. Hodges. Lactam bridge stabilization of a-helices and enhancement of dimerization. In: Peptides: Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 549-551 (1996).

8. Kohn, W.D., O.D. Monera, C.M. Kay and R.S. Hodges. The effects of different salts on the role of interhelical electrostatic repulsions in the stability of two-stranded a-helical coiled-coils. In: Peptides: Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 829-830 (1996).

9. Lavigne, P., L.H. Kondejewski, M.E. Houston, Jr., F.D. Sonnichsen, R.S. Hodges and C.M. Kay. Synthetic max and c- myc leucine zippers preferentially form a heterodomeric parallel coiled-coil. In: Peptides: Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 863-864 (1996).

10. Mant, C.T. and R.S. Hodges. Reversed-phase chromatography as a mimic of ligand-receptor interactions. In: Peptides: Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 46-47 (1996).

11. Wong, W.Y., W. Paranchych, R.S. Hodges, R.T. Irvin. Mapping the adhesintope of the Pilin proteins of Pseudomonas aeruginosa strains PAK and KB7. Peptides: Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 352-353 (1996).

12. Wade, D., P. Semchuk and R.S. Hodges. Synthetic Peptide Vaccine for Pseudomonas Aeruginosa. In: Peptides: Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium (P. Kaumaya and R.S. Hodges, Eds.) Mayflower Scientific Ltd., England, pp. 796-797 (1996).

13. Yu, L., K.K. Lee, W. Paranchych, R.S. Hodges and R.T. Irvin. Use of synthetic peptides to confirm that the Pseudomonas aeruginosa PAK pilus adhesin and the Candida albicans fimbrial adhesin possess a homologous receptor- binding domain. Molecular Microbiology 19: 1107-1116 (1996).

14. Campbell, A.P., H. Sheth, R.S. Hodges and B.D. Sykes. NMR solution structure of the receptor binding domain of Pseudomonas aeruginosa pili strain P1: Identification of a b-turn. Int. J. Pept. Pro. Res. 48: 539-552 (1996).

15. Kondejewski, L.H., S.W. Farmer, D.S. Wishart, R.E.W. Hancock and R.S. Hodges. Gramicidin S is active against gram negative bacteria. Int. Journal Peptide Protein Res. 47: 460-466 (1996).

16. Hodges, R.S. De novo design of a-helical proteins: Basic research to medical applications. Can. Soc. Biochemistry and Mol. Biol. Boehringer Mannheim Award Lecture. Biochem. Cell Biology 74: 133-154 (1996).

17. Godel, J.C., T.K. Basu, H.F. Pabst, R.S. Hodges, P.E. Hodges and M.L. Ng. Perinatal vitamin A (retinal) status of Northern Canadian mothers and their infants: Effects of age and race. Biol. Neonate 69: 133-139 (1996).

18. Yu, Y., O.D. Monera, R.S. Hodges and P.L. Privalov. Investigation of electrostatic interactions in two-stranded coiled-coils through residue shuffling. Biophysical Chemistry 59: 299-314 (1996).

19. Monera, O.D., F.D. Sonnichsen, L. Hicks, C.M. Kay and R.S. Hodges. The relative positions of alanine residues in the hydrophobic core control the formation of two-stranded or four-stranded a-helical coiled-coils. Protein Engineering 9: 353-363 (1996).

20. Wishart, D.S., L.H. Kondejewski, P.D. Semchuk, B.D. Sykes and R.S. Hodges. A method for the facile solid-phase synthesis of gramicidin S and its analogs. Lett. Pept. Sci. 3: 53-60 (1996).

21. Hanson, M., K.K. Unger, C.T. Mant and R.S. Hodges. Optimization strategies in ultrafast reversed-phase chromatography of proteins. Trends Anal. Chem. 15: 102-110 (1996).

22. Houston, M.E., P. Campbell, B. Lix, C.M. Kay, B.D. Sykes and R.S. Hodges. Lactam bridge stabilization of a-helices: The role of hydrophobicity in controlling dimeric versus monomeric a-helices. Biochemistry 35: 10041-10050 (1996).

23. Court, D.A., F.E. Nargang, H. Steiner, R.S. Hodges, W. Neupert and R. Lill. Role of the intermembrane space domain of the preprotein receptor Tom 22 in protein import into mitochondria. Molecular and Cellular Biology 16: 4035- 4042 (1996).

24. Chao, H., R.S. Hodges, C.M. Kay, S.Y. Gauthier and P.L. Davies. A natural variant of type I antifreeze protein with four ice-binding repeats is a particularly potent antifreeze. Protein Science 5: 1150-1156 (1996).

25. Rothemund, S.E., E. Krause, M. Beyermann, M. Dathe, M. Bienert, R.S. Hodges, B.D. Sykes, F.D. Sonnichsen. Peptide destabilization by D-amino acids in single-stranded amphipathic a-helices. Peptide Research 9: 79-87 (1996).

26. Tripet, B., L. Yu, D. Bautista, W.-Y. Wong, R.T. Irvin and R.S. Hodges. Engineering a de novo designed coiled-coil dimerization domain for rapid detection, purification and characterization of recombinant peptides and proteins. Protein Engineering 9: 1029-1042 (1996).

27. Houston, M.E., A. Wallace, A. Pessi and R.S. Hodges. Use of conformationally restricted secondary structural element to display peptide libraries: A two-stranded a-helical coiled-coil stabilized by lactam bridges. J. Mol. Biol. 262: 270-282 (1996).

28. Kondejewski, L.H., S.W. Farmer, D.S. Wishart, C.M. Kay, R.E.W. Hancock and R.S. Hodges. Modulation of structure and antibacterial and hemolytic activity by ring size in cyclic Gramicidin S analogs. J. Biol. Chem. 271: 25261-25268 (1996).

29. Chao, H., M. Houston, S. Grothe, C.M. Kay, M. O'Connor-McCourt, R.T. Irvin and R.S. Hodges. Kinetic study on the formation of a de novo designed heterodimeric coiled-coil: Use of surface plasmon resonance to monitor the association and dissociation of polypeptide chains. Biochemistry 35: 12175-12185 (1996).

30. Lee, K.K., L. Yu, D.L. Macdonald, W. Paranchych, R.S. Hodges and R.T. Irvin. Anti-adhesin antibodies that recognize a receptor-binding motif (adhesintope) inhibit pilus/fimbrial-mediated adherence of Pseudomonas aeruginosa and Candida albicans to asialo-GM, receptors and human buccal epithelial cell surface receptors. Can. J. Micro. 42: 479-486 (1996).

Bibliography

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• 1996