James R. Hagman Ph.D.

Publications

1. Maier H, Colbert J, Fitzsimmons D, Clark DR, Hagman J. Activation of the early B-cell-specific mb-1 (Ig-alpha) gene by Pax-5 is dependent on an unmethylated Ets binding site. Mol Cell Biol. 2003 Mar;23(6):1946-60.

2. Smith MC, Reeder F, Daniel L, Baramee J, Hagman J. Outcomes of touch therapies during bone marrow transplant. Altern Ther Health Med. 2003 Jan-Feb;9(1):40-9.

3. Sigvardsson M, Clark DR, Fitzsimmons D, Doyle M, Akerblad P, Breslin T, Bilke S, Li R, Yeamans C, Zhang G, Hagman J. Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter. Mol Cell Biol. 2002 Dec;22(24):8539-51.
   

4. Maier, H., and Hagman, J. 2002. Roles of EBF and Pax-5 in B lineage commitment and development. Semin Immunol. Dec;14(6):415-22

5. Hagman, J., and Siu, G. 2001. Transcriptional regulation of early lymphocyte development. In “Transcription Factors,” Bios Scientific Publ., pp.137-158.

6. Makar, K.W., Ugliati, D., Hagman, J., and Holers, V.M. 2001. A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulation. Intl. Immunol., 13:657-664.

7. Johnson, A.D., Fitzsimmons, D., Hagman, J., and Chamberlin, H.M. 2001. EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development. Development, 128:2857-2865.

8. Fitzsimmons, D., Lutz, R., Wheat, W., Chamberlin, H.M., and Hagman, J. 2001. Highly conserved amino acids in Pax and Ets proteins are required for DNA binding and ternary complex assembly. Nucl. Acids Res., 29:4154-4165.

9. Garvie, C., Hagman, J., and Wolberger, C. 2001. Structural studies of Ets-1/Pax5 complex formation on DNA. Molec. Cell, 8:1267-1276.

10. Hagman, J., Wheat, W., Fitzsimmons, D., Hodsdon, W., Negri, J., and Dizon, F. 2000. Pax-5/BSAP: regulator of specific gene expression and differentiation in B lymphocytes. Curr. Top. Micro. Immunol., 245:169-194.

11. Wheat, W., Fitzsimmons, D., Lennox, H., Krautkramer, S.R., Gentile, L.N., McIntosh, L.P., and Hagman, J. 1999. The highly conserved b-hairpin of the paired DNA-binding domain is required for the assembly of Pax:Ets ternary complexes. Mol. Cell. Biol., 19:2231-2241.

12. Wasylyk, B., Hagman, J., and Gutierrez-Hartmann, A. 1998. Ets transcription factors: nuclear effectors
    of the Ras/MAPK signaling pathway. Trends Biochem. Sci., 23:213-216.

13. Fitzsimmons, D., Hodsdon, W., Wheat, W., Maira, S.-M., Wasylyk, B. and Hagman, J. 1996. Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter. Genes & Dev., 10:2198-2211.

14. Wagner, D. H., Hagman, J., Linsley, P.S., Hodsdon, W., Freed J. H. and Newell, M. K. 1996. Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2. J. Exp. Med., 184:1631-1638.