Frank E. Frerman, Ph.D.

Publications

1. Simkovic M, Degala GD, Eaton SS, Frerman FE. Expression of human electron transfer flavoprotein-ubiquinone oxidoreductase from a baculovirus vector: kinetic and spectral characterization of the human protein. Biochem J 2002 Jun 15;364(Pt 3):659-67

2. Rao KS, Vander Velde D, Dwyer TM, Goodman SI, Frerman FE.
   Alternate substrates of human glutaryl-CoA dehydrogenase: structure and reactivity of substrates, and identification of a novel 2-enoyl-CoA product. Biochemistry 2002 Jan 29;41(4):1274-84

3. Chisholm CA, Vavelidis F, Lovell MA, Sweetman L, Roe CR, Roe DS, Frerman FE, Wilson WG. Prenatal diagnosis of multiple acyl-CoA dehydrogenase deficiency: association with elevated alpha-fetoprotein and cystic renal changes. Prenat Diagn 2001 Oct;21(10):856-9

4. Westover JB, Goodman SI, Frerman FE. Binding, hydration, and decarboxylation of the reaction intermediate glutaconyl-coenzyme A by human glutaryl-CoA dehydrogenase. Biochemistry 2001 Nov 20;40(46):14106-14

5. Chohan KK, Jones M, Grossmann JG, Frerman FE, Scrutton NS, Sutcliffe MJ. Protein dynamics enhance electronic coupling in electron transfer complexes. J Biol Chem 2001 Sep 7;276(36):34142-7

6. Dwyer TM, Rao KS, Westover JB, Kim JJ, Frerman FE. The Function of Arg-94 in the Oxidation and Decarboxylation of Glutaryl-CoA by Human Glutaryl-CoA Dehydrogenase. J Biol Chem. 2001 Jan 5;276(1):133-138.

7. Dwyer TM, Rao KS, Goodman SI, Frerman FE. Proton abstraction reaction, steady-state kinetics, and oxidation-reduction potential of human glutaryl-CoA dehydrogenase. Biochemistry. 2000 Sep 19;39(37):11488-99.

8. Dwyer TM, Mortl S, Kemter K, Bacher A, Fauq A, Frerman FE. The intraflavin hydrogen bond in human electron transfer flavoprotein modulates redox potentials and may participate in electron transfer. Biochemistry. 1999 Jul 27;38(30):9735-45.

9. Roberts DL, Salazar D, Fulmer JP, Frerman FE, Kim JJ. Crystal structure of Paracoccus denitrificans electron transfer flavoprotein: structural and electrostatic analysis of a conserved flavin binding domain. Biochemistry. 1999 Feb 16;38(7):1977-89.

10. Griffin KJ, Degala GD, Eisenreich W, Muller F, Bacher A, Frerman FE. 31P-NMR spectroscopy of human and Paracoccus denitrificans electron transfer flavoproteins, and 13C- and 15N-NMR spectroscopy of human electron transfer flavoprotein in the oxidised and reduced states. Eur J Biochem. 1998 Jul 1;255(1):125-32.

11. Salazar D, Zhang L, deGala GD, Frerman FE. Expression and characterization of two pathogenic mutations in human electron transfer flavoprotein. J Biol Chem. 1997 Oct 17;272(42):26425-33.

12. Griffin KJ, Dwyer TM, Manning MC, Meyer JD, Carpenter JF, Frerman FE. alphaT244M mutation affects the redox, kinetic, and in vitro folding properties of Paracoccus denitrificans electron transfer flavoprotein. Biochemistry. 1997 Apr 8;36(14):4194-202.

13. Roberts DL, Frerman FE, Kim JJ. Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14355-60.