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John Cambier, Ph.D.
Publications 2000
184) Vely, F., Olivero, S., Olcese, L., Moretta, A., Damen, J.E., Liu, L.,
Krystal, G., Cambier, J.C., Daeron, M. and Vivier, E. 1997. Differential association
of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based
inhibition motifs.European Journal of Immunology. 27:1994-2000.
185) Tamir, I. and Cambier, J.C. 1998. Antigen receptor signaling: integration
of protein tyrosine kinase functions. Oncogene. 17:1353-1364.
186) Rozdzial, M.M., Pleiman, C.M., Cambier, J.C. and Finkel, T.H. 1998. pp56Lck
mediates TCR zeta-chain binding to the microfilament cytoskeleton. Journal of
Immunology. 161:5491-5499.
187) Pao, L.I., Famiglietti, S.J. and Cambier, J.C. 1998. Asymmetrical phosphorylation
and function of immunoreceptor tyrosine-based activation motif tyrosines in B
cell antigen receptor signal transduction. Journal of Immunology. 160:3305-3314.
188) Nakamura, K. and Cambier, J.C. 1998. B cell antigen receptor (BCR)-mediated
formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation.
Journal of Immunology. 161:684-691.
189) Melamed, D., Benschop, R.J., Cambier, J.C. and Nemazee, D. 1998. Developmental
regulation of B lymphocyte immune tolerance compartmentalizes clonal selection
from receptor selection. Cell. 92:173-182.
190) Malbec, O., Fong, D.C., Turner, M., Tybulewicz, V.L., Cambier, J.C., Fridman,
W.H. and Daeron, M. 1998. Fc epsilon receptor I-associated lyn-dependent phosphorylation
of Fc gamma receptor IIB during negative regulation of mast cell activation. Journal
of Immunology. 160:1647-1658.
191) Kouskoff, V., Famiglietti, S., Lacaud, G., Lang, P., Rider, J.E., Kay,
B.K., Cambier, J.C. and Nemazee, D. 1998. Antigens varying in affinity for the
B cell receptor induce differential B lymphocyte responses. Journal of Experimental
Medicine. 188:1453-1464.
192) Witter, D.J., Famiglietti, S.J., Cambier, J.C. and Castelhano, A.L. 1998.
Design and synthesis of SH3 domain binding ligands: modifications of the consensus
sequence XPpXP. Bioorganic & Medicinal Chemistry Letters. 8:3137-3142.
193) Venkataraman, C., Chelvarajan, R.L., Cambier, J.C. and Bondada, S. 1998.
Interleukin-4 overcomes the negative influence of cyclic AMP accumulation on antigen
receptor stimulated B lymphocytes. Molecular Immunology. 35:997-1014.
194) Venkataraman, C., Lu, P.J., Buhl, A.M., Chen, C.S., Cambier, J.C. and
Bondada, S. 1998. CD72-mediated B cell activation involves recruitment of CD19
and activation of phosphatidylinositol 3-kinase. European Journal of Immunology.
28:3003-3016.
195) Cambier, J.C. and Tamir, I. 1998. Signal transduction and cell fate decisions
in the immune system. Enciclopedia Italiana. Estratto Dal Volvme II. III:425-436.
196) Buhl, A.M. and Cambier, J.C. 1999. Phosphorylation of CD19 Y484 and Y515,
and linked activation of phosphatidylinositol 3-kinase, are required for B cell
antigen receptor-mediated activation of Bruton's tyrosine kinase. Journal of Immunology.
162(8):4438-4446.
197) Benschop, R.J. and Cambier, J C. 1999. B cell development: signal transduction
by antigen receptors and their surrogates. Current Opinion in Immunology. 11(2):143-151.
198) Vilen, B.J., Nakamura, T. and Cambier, J.C. 1999. Antigen-stimulated dissociation
of BCR mIg from Ig-alpha/Ig-beta: implications for receptor desensitization. Immunity.
10(2):239-248.
199) Famiglietti, S.J., Nakamura, K. and Cambier, J.C. 1999. Unique features
of SHIP, SHP-1 and SHP-2 binding to FcgammaRIIb revealed by surface plasmon resonance
analysis. Immunology Letters. 68(1):35-40.
200) Benschop, R.J., Melamed, D., Nemazee, D., Cambier, J.C. 1999. Distinct
signal thresholds for the unique antigen receptor-linked gene expression programs
in mature and immature B cells. Journal of Experimental Medicine. 190(6):749-756.
201) Cambier, J.C., Fong, D. and Tamir, I. 1999. The unexpected complexity
of FC gamma RIIB signal transduction. Current Topics in Microbiological Immunology.
244:43-55.
202) Fong, D.C. and Cambier, J.C. 1999. Inhibitory receptors and their modes
of action. Cold Spring Harbor Symposia on Quantitative Biology. LXIV:329-334.
203) Nakamura, K., Brauweiler, A., Cambier, J.C. 2000. Effects of Src Homology
Domain 2 (SH2)-Containing Inositol Phosphatase (SHIP), SH2-Containing Phosphotyrosine
Phosphatase (SHP)-1, and SHP-2 SH2 Decoy Proteins on FcRIIB1-Effector Interactions
and Inhibitory Functions Journal of Immunology. 164(2):631-638.
204) Chumley, M.J., J.M. Dal Porto, S. Kawaguchi, J.C. Cambier, D. Nemazee,
and R.R. Hardy. 2000. A VH11Vkappa9 B cell antigen receptor drives generation
of CD5+ B cells both In vivo and In vitro. Journal of Immunology. 164:4586-4593.
205) Brauweiler, A., I. Tamir, J. Dal Porto, R.J. Benschop, C.D. Helgason,
R.K. Humphries, J.H. Freed, and J.C. Cambier. 2000. Differential Regulation of
B Cell Development, Activation, and Death by the Src Homology 2 Domain-containing
5' Inositol Phosphatase (SHIP). Journal of Experimental Medicine. 191:1545-1554.
206) Tamir, I., Dal Porto, J.M. and Cambier, J.C. 2000. Cytoplasmic protein
tyrosine phosphatases SHP-1 and SHP-2: Regulators of B cell signal transduction.
Current Opinion in Immunology. 12(3):307-315.
207) Buhl, A.M., Nemazee, D., Cambier, J.C., Rickert, R. and Hertz, M. 2000.
B-cell antigen receptor competence regulates B-lymphocyte selection and survival.
Immunological Reviews. 176:141-153.
208) Brauweiler, A., Tamir, I., and Cambier, J.C. 2000. Bi-level control of
B cell activation by the Inositol 5-Phosphatase, SHIP. Immunological Reviews.
176:69-74.
209) Fong, D., Brauweiler, A., Minskoff, S.A., Bruhns, P., Tamir, I., Mellman,
I., Daeron, M., Cambier, J. 2000. Mutational analysis reveals multiple distinct
sites within Fcg receptor IIB that function in inhibitory signaling. J. Immunol.
165:4453-4462.
210) Giallourakis, C., Kashiwada, M., Pan, P-Y., Danial, N., Jiang, H., Cambier,
J., Coggeshall, K.M., Rothman, P. 2000. Positive regulation of interleukin-4-mediated
proliferation by theSH2-containing inositol-5'-phosphatase. J. Biol. Chem. 275(38):29275-29282.
211) Ott, V.L. and Cambier, J.C. 2000. Activating an inhibitory signaling in
mast cells: New opportunities for therapeutic intervention? J Allergy and Clin
Immunol. 106:429-40.
212) Kepley, C.L., Cambier, J.C., Morel, P.A., Lujan, D., Ortega, E., Wilson,
B.S., Oliver, J.M. 2000. Negative regulation of FceRI signaling by FcgRII costimulaiton
in human blood basophils. J Allergy Clin Immunol. 106:337-48.
213) Tamir, I., Stolpa, J.C., Helgason, C.D., Nakamura, K., Bruhns, P., Daeron,
M., and Cambier, J.C. 2000. The RasGAP-binding protein p62dok is a mediator
of inhibitory FcgRIIB signals in B cells. Immunity. 12:347-358.
Publications
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